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The total population of Santa Isabel Municipio is estimated to be 20,207 with 9,702 males (48.01%) and 10,505 females (51.99%). There are 803 more females than males in Santa Isabel Municipio.
The median age in Santa Isabel Municipio, PR is 40.3, as per 2021 ACS 5-Year Estimates. Of the total population, 16.10% were under the age of 15, 21.58% aged 15 to 29, 45.73% aged 30 to 64, 14.90% aged 65 to 84, and 1.69% were 85 years of age and older.
Racial distribution of Santa Isabel Municipio population: 37.20% are White, 25.04% are Black or African American, 0.10% are American Indian and Alaska Native, 3.65% are some other race and 34.01% are multiracial.